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The impact of iterative minimum mean square error (MMSE) detection on multisensor signaling schemes in frequency-selective media is considered. The suitability of a decision-feedback MMSE (DF-MMSE) front end relative to a linear MMSE (LMMSE) front end is examined using two case studies, namely, layered spatial-multiplexing and block-orthogonal space-time signaling. Iterative MMSE detection is observed to afford near-optimal performance. Further, in channels with large delay spreads, a combination of the LMMSE and DF-MMSE front ends seems appropriate: the former in earlier iterations and the latter in concluding iterations.