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Innovative circuits and systems techniques are required to build advanced smart medical devices (SMD). The high reliability and very low power consumption are among the main criteria that must be given priority to implement in such implantable and wirelessly controlled microsystems. A typical device is composed of several integrated modules to be assembled on a thin substrate providing placement flexibility in the body. Monitoring of electrode-tissue interface condition is needed for enhanced safety, and for enabling troubleshooting after implantation. In order to improve controllability and observability, fully integrated binary phase-shift-keying (BPSK) demodulation combined with a passive modulation method allows full-duplex data high data rate communication between external controllers and implants. Case studies such as peripheral nerve interfaces to recuperate bladder functions, cortical multichannel stimulator, as well as cortical monitoring devices are reported.