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Biomimetic scaffolds for tissue engineering

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2 Author(s)
Bhatnagar, R.S. ; Dept. of Bioeng., California Univ., Berkeley, CA, USA ; Song Li

A major goal of tissue engineering is to generate living cellular constructs with 3-D, tissue-like organization of cells and matrices. The generation of mechanical forces by the cellular cytoskeleton plays a critical role in the organization of matrix and of cellular colonies. The anchorage of the cytoskeleton to a substrate is essential for cellular tractional processes. We show that placing cells in scaffolds which contain a collagen-related synthetic peptide P-15 allows them to generate highly organized 3-D colonies and matrices. These observations suggest that P-15 may replicate cells' physiological collagen anchorage.

Published in:

Engineering in Medicine and Biology Society, 2004. IEMBS '04. 26th Annual International Conference of the IEEE  (Volume:2 )

Date of Conference:

1-5 Sept. 2004