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Cellular function prediction and biological pathway discovery in Arabidopsis thaliana using microarray data

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4 Author(s)
Trupti Joshi ; Dept. of Comput. Sci., Missouri-Columbia Univ., Columbia, MO, USA ; Yu Chen ; Alexandrov, N. ; Dong Xu

We have developed a new integrated probabilistic method for cellular function prediction by using microarray gene expression profiles, in conjunction with predicted protein-protein interactions and annotations of known proteins through an integrative statistical model. Our approach is based on a novel assessment for the relationship between correlation of two genes' expression profiles and their functional relationship in terms of the gene ontology (GO) hierarchy. We applied the method for function predictions of hypothetical genes in Arabidopsis. We have also extended our computational method using Dijkstra's algorithm to identify the components and topology of a pathway, and we applied it for predicting the signaling pathway of phosphatidic acid as a second messenger in Arabidopsis.

Published in:

Engineering in Medicine and Biology Society, 2004. IEMBS '04. 26th Annual International Conference of the IEEE  (Volume:2 )

Date of Conference:

1-5 Sept. 2004