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Synthetic gene oscillators by negative feedback networks

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3 Author(s)
Ruiqi Wang ; Osaka Sangyo Univ., Japan ; Zhou, T. ; Luonan Chen

We aim at developing a new methodology to model and design periodic oscillators of gene regulatory networks with multiple genes, proteins and time delays, by using multiple time-scale networks (MTN). Multiple time scale properties are exploited to simplify the model according to singular perturbation theory. We show that a MTN has no stable equilibria but stable periodic orbits. Finally, we design a biologically plausible gene oscillator by cI and Lac genes, to demonstrate our theoretical results.

Published in:

Engineering in Medicine and Biology Society, 2004. IEMBS '04. 26th Annual International Conference of the IEEE  (Volume:2 )

Date of Conference:

1-5 Sept. 2004