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One current focus in diffusion tensor imaging is the validation of DT-MR measurements against histological slices. Current methods require manual correlation by visual inspection. We present algorithms which automatically analyze spinal cord histology slices based on Fourier and morphological operators. They accurately discriminate regions dominated by in-plane caudal-cranial fibers from in-plane axial fiber dominated regions, and can then be used to validate angular direction, anisotropy, and relative eigenvalue estimates from DT-MR.