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Estimation of ethanol infusion profile to produce specified BrAC time course using physiologically-based pharmacokinetic (PBPK) models

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4 Author(s)
Plawecki, M.H. ; Dept. of Biomedical Eng., Purdue Univ., West Lafayette, IN, USA ; Decarlo, R.A. ; Ramchandani, V.A. ; O'Connor, S.

A procedure for estimating the alcohol infusion profile required to produce a specific breath alcohol concentration (BrAC) time course using a PBPK model is described. Model parameter values are predicted from linear relationships to readily measurable physical characteristics or morphometrics. An algorithm to optimize this transformation, based upon recorded clinical experimental data, is provided. A substantial improvement in all error statistics, in relation to the original transform was obtained.

Published in:

Engineering in Medicine and Biology Society, 2004. IEMBS '04. 26th Annual International Conference of the IEEE  (Volume:1 )

Date of Conference:

1-5 Sept. 2004