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This work presents a novel simulated model for a wireless data acquisition system. The system reads analogue information provided by two sensors and can be used for medical purposes. Real data has been obtained and a simulation of the two signals coming from both pH and pressure sensors embedded in the system has been employed. The created model contains four main units simulated using SIMULINK. At the first unit, the output signal is encoded to digital signal based on adapting one of the pulse coding modulation (PCM) algorithms. The second unit simulates the processor function that is responsible for framing, mixing and compressing the incoming bit streams from both sensors. The third unit, where the digital data is modulated and sent through different noisy channels, represents an efficient FSK transmitter/receiver model. At the receiver end, the signal is demodulated and processed inversely to extract the original analogue signal read by the two sensors. In this work, the performances of the systems using different PCM methods are studied comparatively in order to control the transmission and reduce the amount of data sent. This leads to a significant reduction in power consumption. In addition, efficiency of the RF channel in terms of bit error rate (BER) and through different noisy conditions is investigated.