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This work gives an overview of the articles contained in the theme section of an issue of IEEE Engineering in Medicine and Biology Magazine. The manuscripts found in this magazine are from a series of presentations given as part of the "Uncovering the Mechanisms of Movement and Sensation using Transcranial Magnetic Stimulation (TMS)" symposium held during the XVth Congress of the International Society of Electrophysiology and Kinesology, Boston, USA, 18-21 June 2004. This symposium was conceived as an effort to strengthen communication and integration among movement scientists from the subdisciplines of neurology, clinical neurophysiology, basic and clinical neuroscience, physical therapy, biomechanics, biomedical engineering, robotics, and clinical care. Specifically, the symposium's aim was to generate a novel synthesis of basic science and clinical mechanisms of motor cortex plasticity and thus facilitate the design of rehabilitation programs.