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Experimental evidences suggest involvement of the hippocampus in temporal sequence learning. Taking physiological differences between the hippocampal CA3 and CA1 regions into account, we propose a mechanism of temporal sequence encoding. Input signals that mimicked the activity of the rat entorhinal cortex during animal's spatial behavior were applied to a model hippocampal CA3-CA1 network. Following an organization of spatiotemporal patterns of spontaneous activity in the CA3 region, Schaffer collateral synaptic conductances were modified eventually forming a distinct spatial pattern. As a result, a CA1 pyramidal cell assembly was tuned to a specific sequence of input signals.