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A global optimization technique is applied to solve the optimal transmitter placement problem for indoor wireless systems. An efficient pattern search algorithm - DIviding RECTangles (DIRECT) of Jones et al.- has been connected to a parallel three-dimensional radio propagation ray tracing modeler running on a 200-node Beowulf cluster of Linux workstations. Surrogate functions for a parallel wideband code-division multiple-access (WCDMA) simulator were used to estimate the system performance for the global optimization algorithm. Power coverage and bit-error rate are considered as two different criteria for optimizing locations of a specified number of transmitters across the feasible region of the design space. This paper briefly describes the underlying radio propagation and WCDMA simulations and focuses on the design issues of the optimization loop.