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This paper describes the application of a master/slave configuration of processors to study a comparison of alternative material handling configurations for automated manufacturing. Such a study usually requires a large number of simulation replications, and carrying out those replications on a multi-processor platform yields significant savings in elapsed time. In the present application, a master processor carries out the statistical computations for a 2k factorial design on up to eight slave processors. This paper will compare the results from using two, four and eight processors.