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0.13-μm radio frequency (RF) CMOS devices with multifinger gate structure have been fabricated by the standard logic process, and the measured effective gate-length is 80 nm. Extensive RF characterization has been done to obtain cutoff frequency (fT), associated power gain cutoff frequency (fmax), minimum noise figure (NFmin), output power (Pout), and power added efficiency (PAE) for RF circuit design and to explore the optimized gate layout in terms of the extracted RF device parameters. Our important finding to be reported in this paper is that an optimized unit finger width (WF) exists by trade-off among fT, fmax, NFmin, Pout, and PAE. Under fixed total width to achieve the same current drivability (Ids), the smaller WF and the larger finger number (NF) leads to higher fmax but lower fT due to trade-off between gate resistance (Rg) and parasitic gate capacitance. As for NFmin complicated by fT and Rg, counter-balance between parasitic gate capacitance and Rg leads to nearly constant NFmin w.r.t. various splits of (WF,NF). Regarding Pout and PAE, WF of 4 μm and NF of 18 is the optimized layout parameter, which offers the maximum Pout of around 11 dBm and PAE of 30.5% at 5.8 GHz. The performances of accumulation-mode MOS varactors with different gate layout structures are also investigated in this report. Since the same area varactors with different gate layout may result in different parasitic resistance and fringing capacitance, which will affect the capacitance tuning range and the associated Q-factor. The maximum Q-factor is about 59 of the 120 μm2 gate area varactor, and its tuning range is from 210 fF to 1.64 pF, where the maximum Cmax/Cmin ratio is about 7.8.