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Cell-based CMOS sensor and actuator arrays

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4 Author(s)
Jenkner, M. ; Corporate Res., Infineon Technol. AG, Munich, Germany ; Tartagni, M. ; Hierlemann, A. ; Thewes, R.

In recent years, increasing knowledge about in vitro cell handling and culturing has encouraged a variety of CMOS-based approaches to stimulate and detect electrical activity of biological cells. This paper outlines in a topical review the scope of cell-based biosensors and actuators for in vitro applications ranging from single-cell detection to multisite probing of complex neural tissue. Recent examples are selected to demonstrate how standard CMOS processes have been used to engineer arrays with different functionality.

Published in:

Solid-State Circuits, IEEE Journal of  (Volume:39 ,  Issue: 12 )

Date of Publication:

Dec. 2004

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