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Under the background of the gas-fluidized polyethylene reactor, this paper studied the framework and implementation of computer integrated control system for the industrial process equipment. First, on the basis of technique characters and design requirements of the control system, a four-tie system framework including process layer, data layer, control layer and user interface layer was proposed and functions were respectively analyzed. Then based on the full consideration of polyethylene techniques, the design of real-time database, Web-based process monitor user interface and data interchange in between the control layers were emphatically discussed. Finally, the industry actual application of the system was briefly analyzed.