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As bacterial genomic data accumulates in the public domain and the price of genomic sequencing falls, comparative-sequencing projects between multiple strains become an affordable option for both medical microbiologists and commercial firms interested in large-scale fermentation. To meet this need, biotech firms like MWG must first build up experience in bacterial whole genome sequencing and detailed gene annotation. There is also a need to combine this experience with bioinformatics and know how to be able to carry out useful comparative strain analysis. Finally, flexibility with bioinformatics and software offering to "customerize" the project to meet individual needs are necessary. It is believed that the approach outlined is an ideal and affordable way to tackle the issue of comparative sequence analysis.
Engineering in Medicine and Biology Magazine, IEEE (Volume:23 , Issue: 4 )
Date of Publication: July-Aug. 2004