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GeneTide - Terra Incognita Discovery Endeavor mining ESTs and expression data to elucidate known and de-novo GeneCards® genes

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6 Author(s)
Shklar, M. ; Dept. of Molecular Genetics, Weizmann Inst. of Sci., Rehovot, Israel ; Shmueli, O. ; Strichman-Almashanu, L. ; Shmoish, M.
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The construction of a complete EST-based gene index is an intricate task yet to be accomplished. GeneTide, the Gene Terra Incognita Discovery Endeavor (, which is the newest addition to the GeneCards suite of databases, comprehensively maps >4.5 of the ∼5.5 million human ESTs currently available at dbEST with either known or newly defined putative human genes. The association is accomplished via data mining genomic resources, and integrating using a unified scoring scheme. Groups of unassociated transcripts serve as a basis for defining EST-based gene candidates (EGCs). These EGCs are annotated with various parameters, including expression data, to determine their validity as possible de-novo genes. An immediate application of GeneTide to microarray annotation has increased, in a specific example, the number of annotated Affymetrix HGU95A-E probe sets by 50% in comparison to previous attempts.

Published in:

Computational Systems Bioinformatics Conference, 2004. CSB 2004. Proceedings. 2004 IEEE

Date of Conference:

16-19 Aug. 2004