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This paper presents the conception, design, implementation, and validation of an original, fully functional biosensor based on surface plasmon resonance (SPR) technology. We present the motivation for building this sensor followed by the system specification, a brief overview of the theory of operation for SPR physics, and then give a detailed description of the hardware design, software design, and immunoassay design. We present a novel, graphical approach for tracking shifts in SPR center frequency with an autocorrelation feature that minimizes component variation. Additionally, we present the wireless communications aspects of our design, which adds to its appeal for remote system deployment and autonomous operation. Our success demonstrates the immediate availability of all the hardware, software, and biological components required to construct a fully functional biosensor with industrial application.
Date of Publication: Oct. 2004