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Nitric oxide (NO) serves as an important intercellular messenger in the human body, and is mechanistically involved in vascular disease, stroke, chronic hear failure, and epilepsy. We present a multi-electrode NO measurement sensor with integrated microfluidics. An array of carbon-based electrodes detect the spatial and temporal diffusion profile of NO in a PDMS laminar fluidic channel. The array interfaces to a multichannel potentiostatic VLSI system recording the amperometric output in real time, with five orders of magnitude in dynamic range over four scales down to hundreds of picoamperes. The integrated sensor-fluidic-VLSI system is expected to serve as a powerful tool to study the diffusion mechanism of NO under different fluid flow paradigms.