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Vibro-acoustography is a recently developed imaging method based on the dynamic response of to low-frequency vibration produced by of ultrasound radiation force. The main differentiating feature of this method is that the image includes information about the dynamic properties of the object at the frequency of the vibration, which is normally much lower than the ultrasound frequency. Such information is not available from conventional ultrasound imaging. The purpose of this study is to evaluate the performance of vibro-acoustography in imaging mass lesions in soft tissue. Such lesions normally have elastic properties that are different from the surrounding tissue. Here, we first present a brief formulation of image formation in vibro-acoustography. Then we study vibro-acoustography of solid masses through computer simulation and in vitro experiments. Experiments are conducted on excised fixed liver tissues. Resulting images show lesions with enhanced boundary and often with distinctive textures relative to their background. The results suggest that vibro-acoustography maybe a clinically useful imaging modality for detection of mass lesions.