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In recent years, various types of applications of electromagnetic techniques to microwave thermal therapies have been developed. The authors have been studying the coaxial-slot antenna, which is one of the thin microwave antennas, for the minimally invasive microwave thermal therapies, such as interstitial microwave hyperthermia. From the results of our previous studies, it was clear that the coaxial-slot antenna with two slots generates a localized heating region only around the tip of the antenna. In this paper, we confirm the heating characteristics of the coaxial-slot antennas with two slots from a viewpoint of clinical use, and introduce the results of two clinical trials.