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Detection of 100 spots parallel DNA:DNA interactions on polymer-functionalized surfaces using surface plasmon resonance imaging

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8 Author(s)
Bassil, N. ; Lab. Charles Fabry de l''lnst. d''Opt., Univ. Paris XI, Orsay, France ; Maillart, E. ; Canva, M. ; Levy, Yves
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Surface plasmon resonance is a method well-known for its sensibility to refractive index variations at a metal-dielectric interface. Surface plasmon imaging is an extension of this method. It allows the local study of refractive index variations resulting from interfacial modifications on a metallic surface. This technique is suitable to monitor in parallel, in real time and without any label hundreds of molecular interactions. The study of DNA:DNA hybridization is one of its applications.

Published in:

Lasers and Electro-Optics Europe, 2003. CLEO/Europe. 2003 Conference on

Date of Conference:

22-27 June 2003