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This paper proposes the notion of an agent-based grid computing infrastructure (AGCI), which is developed to help manage the healthcare processes in real world settings. For healthcare practitioners and policy makers, the proposed agent-based grid approach will allow to combine patient records from vast number of hospitals, providing important of new data in the search for patient cures and treatments. The design and methodology of AGCI framework is based on globus and control of agent-based systems. The emerging intelligent agent-based grid framework applied to the healthcare domain provides interesting opportunities to operationalize the volumes of healthcare data routinely collected within numerous healthcare enterprises.