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Biological systems are important source of inspiration for design and development of intelligent computational systems. This is because biological systems have intrinsic potential for evolution and adaptation. Artificial immune system (AIS) is a computational system designed on the principles of natural immune system (IS), which is highly distributed, adaptive and diverse system. This is a novel and rapidly growing approach for solving complex computational problems. The artificial immune system (AIS) research, being interdisciplinary, demands significant knowledge of immunology and computational science. This paper describes one of the pioneering efforts for AIS research in Malaysia, which is the reverse engineering of LISYS.