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The capacity of wireless networks can be increased via dynamic load balancing/sharing by employing overlay networks on top of the existing cellular networks. One such recently proposed system is the integrated cellular and ad hoc relay (iCAR) system, where an overlay ad hoc network is employed to use the resources efficiently by dynamically balancing the load of the hot spots in the cellular network, and to provide quality-of-service to subscribers, no matter where they are located and when the request is made. It is assumed that this overlay network operates in the 2.4-GHz Industrial, Scientific, and Medical (ISM) band and, hence, the number of available ISM-band relay channels used for load balancing will be limited due to other users' interference at a given point in time. In this paper, the impact of ISM-band interference on the performance of iCAR systems, which is a representative hybrid wireless network, is studied, and it is shown that dynamic load balancing and sharing capabilities of iCAR systems are strictly dependent on the availability of the ISM-band relay channels. In addition to quantifying the impact of the number of available relay channels on the performance of iCAR systems, a simple channel assignment scheme to reduce the performance degradation due to other users' interference is also provided. Results show that this interference avoidance technique can improve the realistic performance of iCAR-like hybrid wireless networks by 12%-23% when the interferers are uniformly distributed in the ISM-band.