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Detection of Polymer-shelled ultrasound contrast agents using a signal subtraction method

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5 Author(s)
Bloch, Susannah H. ; Dept. of Biomed. Eng., California Univ., Davis, CA, USA ; Patel, D.L. ; Dayton, P.A. ; Wan, Mingxi
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Polymer-shelled contrast agents demonstrate unique properties because the enclosed gas oscillates freely only after the shell is damaged. We have observed this behavior optically using a high-speed camera, and hypothesize that it leads to the observed acoustical property that the response of a polymer-shelled bubble to a two-pulse sequence depends on the order of pulse transmission. We have observed this property in two different polymer-shelled contrast agents. Based on these findings, we designed a pulse sequence to detect polymer-shelled bubbles, "signal subtraction", in which two same-phase single-cycle pulses are transmitted in succession and the resulting echoes subtracted. This subtraction results in the cancellation of tissue echoes, even in the presence of tissue harmonic generation, with only a small reduction in bubble signal amplitude.

Published in:

Ultrasonics, 2003 IEEE Symposium on  (Volume:1 )

Date of Conference:

5-8 Oct. 2003