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Spiral wave meandering in models of ventricular tissue as an antiarrhythmic target

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2 Author(s)
Kremmydas, G.P. ; LUMC-KI, Argostoli, Greece ; Holden, A.V.

We characterise the effects of ionic conductance and concentration changes on the meandering patterns and dynamics of re-entrant excitation in models of mammalian ventricular tissue. An increase in the spatial extent of spiral wave meander might lead to an increased likelihood of self-termination of the re-entrant excitation, since the probability of the spiral core meeting and annihilating at the in-excitable tissue boundaries is increased. Thus, the spiral-wave meandering behaviour and dynamics provides a potential target for antiarrhythmic drugs.

Published in:

Computers in Cardiology, 2003

Date of Conference:

21-24 Sept. 2003

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