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Inhibition of atrial action potentials alternans by calcium-activated chloride current blockade - simulation study

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3 Author(s)
Gomis-Tena, J. ; Centro de Investigacion e Innovacion en Bioingenieria, Univ. Politecnica de Valencia, Spain ; Saiz, J. ; Ferrero, J.M.

Atrial fibrillation (AF) is the most common cardiac arrhythmia. Atrial action potential (AP) alternans appearance during atrial flutter play a determinant role as AF precursor. AP alternans involves intracellular calcium concentration alternation that affects calcium dependent currents like INaCa und IClCa. In this study, a modified rabbit atrial AP mode, that includes IClCa formulation is used. In order to induce alternans, the pacing cycle length was abruptly shortened from a basic drive of 1000 ms after 7.5 s of stimulation. The role of IClCawas investigated by blocking the current. When increasing pace rate, from a cycle length of 1000 ms to 180 ms, beat-to-beat alternans appear. Repeating the procedure in IClCablockade situation, in the range of 60 to 100 %, alternans disappear. Our results suggest that IClCa blockade prevents alternans and for this reason IClCa blockade could be potentially antiarrhythmic, preventing AF.

Published in:

Computers in Cardiology, 2003

Date of Conference:

21-24 Sept. 2003