Cart (Loading....) | Create Account
Close category search window

Effects of the antiarrhythmic drug dofetilide on myocardial electrical activity: a computer modelling study

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

6 Author(s)
Saiz, J. ; Centre for Res. & Innovation on Bioengineering, Valencia, Spain ; Ferrero, J.M. ; Monserrat, M. ; Gomis-Tena, J.
more authors

Dofetilide selectively inhibits the rapid component of the delayed potassium current (IKr). In this work, a mathematical model of dofetilide effects on IKr has been developed. This model has been incorporated to the Luo and Rudy (II) model of guinea pig ventricular action potential and the effect of different dofetilide concentrations on the action potential characteristics has been studied. Our results show that the steady-state block of IKr is dose-dependent with a block of 10%, 53% and 92% for 1 nM, 10 nM and 100 nM of dofetilide respectively (IC50=8.7 nM). This increment of IKr block when the concentration increases induces a prolongation of APD also in a dose-dependent way. We observed prolongations of APD90 of 13% and 28% for 10 nM and 100 nM of dofetilide respectively. In agreement with experimental results, the interaction between dofetilide and the receptor in the channel presents slow kinetics and reverse use-dependence in our model.

Published in:

Computers in Cardiology, 2003

Date of Conference:

21-24 Sept. 2003

Need Help?

IEEE Advancing Technology for Humanity About IEEE Xplore | Contact | Help | Terms of Use | Nondiscrimination Policy | Site Map | Privacy & Opting Out of Cookies

A not-for-profit organization, IEEE is the world's largest professional association for the advancement of technology.
© Copyright 2014 IEEE - All rights reserved. Use of this web site signifies your agreement to the terms and conditions.