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The motivation of this research is to improve the ability of ambulation for people with a certain degree of disability. The control method is using two tilt sensors as an input-controlling module. One of the tilt sensors detects the anterior/posterior tilting of the head and moves the wheelchair or mouse cursor forward/backward, the other distinguishes the left/right swing of the head. In order to increase the safety of this system, the M3S protocol established by the European Commission is also applied to this research. The system based on M3S protocol has the advantage of real-time monitoring for people with severe disabilities.