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In this paper, a Computer Aided Diagnosis (CAD) system for the characterization of hepatic tissue from Computed Tomography (CT) images is presented. Regions of Interest (ROI's) corresponding to normal liver, cyst, hemangioma, and hepatocellular carcinoma, are drawn by an experienced radiologist on abdominal nonenhanced CT images. For each ROI, five distinct sets of texture features are extracted using the following methods: first order statistics, spatial gray level dependence matrix, gray level difference method, Laws' texture energy measures, and fractal dimension measurements. If the dimensionality of a feature set is greater than a predefined threshold, feature selection based on a Genetic Algorithm (GA) is applied. Classification of the ROI is then carried out by a system of five neural networks (NNs), each using as input one of the above feature sets. The members of the NN system (primary classifiers) are 4-class NNs trained by the backpropagation algorithm with adaptive learning rate and momentum. The final decision of the CAD system is based on the application of a voting scheme across the outputs of the individual NNs. The multiple classification scheme using the five sets of texture features results in significantly enhanced performance, as compared to the classification performance of the individual primary classifiers.