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This paper presents a thorough investigation into the effects of several phone chassis-related parameters-length, width, thickness, and distance between the head and phone-on the bandwidth, efficiency, and specific absorption rate (SAR) characteristics of internal mobile phone antennas. The studied antenna-chassis combinations are located beside an anatomical head model in a position of actual handset use. The effect of the user's hand is also studied with two different hand models. The main part of the study is based on FDTD simulations, but also experimental results, which support the computationally obtained conclusions, are given. The presented analysis provides novel and useful information for future design of mobile handset antennas. The results show the general trends of bandwidth, SAR, and efficiency with different chassis parameters. The results also reveal a connection between these three performance parameters: an increase in SARs and a decrease in radiation efficiency occur compared to the general trend when the bandwidth reaches its maximum. This happens when the resonant frequency of the chassis equals that of the antenna.