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Nonlinear effects are one of the main causes of pulse degradation in high bit-rate transmission systems and several architectures have been proposed to compensate them by means of optical phase conjugation. In this letter, a new method to exploit an optical phase conjugator for nonlinearity cancellation is disclosed. The proposed method is simpler than those previously described in literature and allows a relevant improvement of systems performances. Link-design rules are analytically studied; moreover, their effectiveness is numerically demonstrated for different applications. This technique can apply to any bit rates and modulation formats.