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Just as the Internet is shifting its focus from information and communication to a knowledge delivery infrastructure, we see the Grid moving from computation and data management to a pervasive, worldwide knowledge management infrastructure. We have the technology to store and access data, but we seem to lack the ability to transform data tombs into useful data and extract knowledge from them. We review some of the current and future technologies that will impact the architecture, computational model, and applications of future grids. We attempt to forecast the evolution of computational grids into what we call the next-generation grid, with a particular focus on the use of semantics and knowledge discovery techniques and services. We propose a comprehensive software architecture for the next-generation grid, which integrates currently available services and components in Semantic Web, Semantic Grid, P2P, and ubiquitous systems. We'll also discuss a case study that shows how some new technologies can improve grid applications.