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The study of interictal transient events may substantially complement the analysis of seizures in the presurgical evaluation of intractable epilepsy. A comprehensive methodology of quantifying reproducibility of activation patterns in intracerebral electroencephalography signals is presented. It may be applied to various forms of transient epileptic events under the assumption that a time of occurrence may be assigned to them. In this paper, the method is used on two different forms of interictal events (interictal spikes or sharpwaves and transient bursts of fast activity). The methodology is based on signal processing and data mining algorithms and proceeds in three steps: (1) detection of transient paroxysmal events (monochannel event); (2) identification of quasisynchronous transient paroxysmal events (multichannel events); and (3) automatic extraction of similar activation patterns. Results show that the methodology allows reproducible sequential activation sets to be identified from signals recorded in four patients. Potential advantages of the method are discussed with respect to other approaches.