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Microdevices for separation, accumulation, and analysis of biological micro- and nanoparticles

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8 Author(s)
J. Kentsch ; Naturwissenschaftliches und Medizinisches Inst., Reutlingen, Germany ; M. Durr ; T. Schnelle ; G. Gradl
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Microfabrication and performance of a novel microsystem for separation, accumulation and analysis of biological micro- and nanoparticles is reported. Versatile chip functions based on dielectrophoresis and microfluidics were integrated to isolate particles from complex sample solutions such as serum. A bead-based assay for virus detection is proposed. Separation of micro- and sub-μm beads employing dielectrophoretic deflector and bandpass structures is demonstrated. Individual antibody coated beads with hepatitis A virus bound to their surface were trapped by negative dielectrophoresis in a field cage and analysed by fluorescence microscopy.

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IEE Proceedings - Nanobiotechnology  (Volume:150 ,  Issue: 2 )