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In this paper, we evaluate the performance of 1× evolution data and voice (1×EV/DV) systems with multiple antennas at both the transmitter and the receiver. The multicode interference (MCI) in 1×EV/DV systems is hard to compensate in multipath fading channels. Especially, the effect of MCI is more severe when using multiple antennas. We can improve the receiver performance by using multipath interference cancellation (MPIC) scheme. Simulation results show that 1×EV/DV systems with the multiple antennas and the MPIC scheme can achieve higher data rate than single antenna system in the frequency selective fading channel.