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Multiple clock cycles are needed to cross the global interconnects for multi-gigahertz designs in nanometer technologies. For synchronous design, this requires the consideration of multi-cycle on-chip communication at the high level. In this paper, we present a new architectural synthesis system integrated with global placement, named MCAS (Multi-Cycle Architectural Synthesis), on top of the recently-proposed Regular Distributed Register (RDR) micro-architecture. The RDR architecture provides a regular synthesis platform for supporting multi-cycle communication. Novel architectural synthesis algorithms that integrate high-level synthesis with global placement have been developed in MCAS, including scheduling-driven placement and distributed controller generation, etc. Experimental results show that our methodology can achieve a clock period improvement of 31% and a total latency improvement of 24% on average compared to the conventional architectural synthesis flow.