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Cardiac cell networks on elastic microgrooved scaffolds

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3 Author(s)
Bien, Harold ; Dept. of Biomed. Eng., Stony Brook Univ., NY, USA ; Lihong Yin ; Entcheva, Emilia

We sought to construct a model-engineered cardiac construct having anisotropic properties and consisting of inter-connected cardiac cells with syncytial tissuelike behavior. We report basic structural, electrophysiological and mechanical characterization of multicellular tissuelike engineered constructs developed using elastic matrices with 3-D surface microtopography. To properly assess functionality of the constructs in the tissue setting, we employed spatial optical fluorescence techniques enabling measurements at the micro- and macro-scale.

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Engineering in Medicine and Biology Magazine, IEEE  (Volume:22 ,  Issue: 5 )