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Quantitative analysis of the fine vascular anatomy of articular ligaments

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6 Author(s)
K. Eng ; Calgary Univ., Alta., Canada ; R. M. Rangayyan ; R. C. Bray ; C. B. Frank
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An image analysis technique has been developed to quantitatively describe the fine vascular patterns observed in ligament tissue. The longitudinal orientational distribution and total vessel volume of India-ink-perfused blood vessel segments in normal and healing ligaments were determined. The methods involved special vascular preparation of adult rabbit knee medial collateral ligaments (MCLs) by India-ink perfusion. Black and white microscope images of ink-perfused tissue sections were subjected to a thresholding procedure to binarize digitized ligament images, which were then skeletonized and analyzed for directional distribution based on the least-squares technique. Analysis of medial collateral ligaments in New Zealand White rabbits using this method has shown that scarred tissue is more vascular and has a more chaotic angular distribution of blood-vessel segments than normal ligament tissue.

Published in:

IEEE Transactions on Biomedical Engineering  (Volume:39 ,  Issue: 3 )