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A grid architecture, called TCM-grid for traditional Chinese medicine, is presented. Based on the open grid service architecture (OGSA), we develop a set of database grid services for discovering and accessing TCM database resources remotely and transparently. Upon these database grid services, a set of knowledge services are also specified to support TCM knowledge sharing in the Web environment. With our application experience, we argue that OGSA be promoted to support finely granular data sharing and knowledge-intensive tasks.