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In this paper, optimized transmit schemes for multiple-input multiple-output (MIMO) systems with simplified receivers are proposed for the downlink of high-speed wireless communication systems. In these systems, MIMO signal preprocessing is performed at the transmitter or base station with the receiver at the mobile station having a simplified structure that requires only limited signal processing. An important potential application for our transmit MIMO techniques is in the downlink of high-speed wireless communication systems with Vertical Bell Laboratories Layered Space-Time (V-BLAST) or a similar technique utilized in the uplink, creating a high-speed duplex system with a simplified mobile station transceiver structure. Two approaches are introduced and these depend on whether or not receive diversity is employed at the receiver. Both methods require that channel state information be available at the transmitter. In addition, some important associated issues such as peak-to-average power ratio requirements at the transmitter and robustness to downlink channel errors are also investigated and various solutions are proposed. Simulation results are provided and these show that performance improvement can be achieved when compared with other MIMO transmit schemes.