By Topic

Nano/micro technologies for single molecule manipulation and detection

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$33 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

2 Author(s)
Tza-Huei Wang ; Dept. of Mech. Eng., Johns Hopkins Univ., Baltimore, MD, USA ; Chih-Ming Ho

A sensitive, rapid, and efficient single-molecule detection method was developed by combining fluorescence correlation spectroscopy (FCS) and on-chip molecular manipulation techniques. The highly restricted measurement volume in the FCS system significantly reduces the intrinsic background noise and facilitates single-molecule sensitivity. A microchannel integrated with multiple 3-D electrodes was fabricated and used for molecular sensing and manipulation by which individual DNA molecules were fast transported to and sequentially focused within the tiny probing volume for measuring single-molecular information, thereby enhancing both the efficiency and rates of detection.

Published in:

Robotics and Automation, 2003. Proceedings. ICRA '03. IEEE International Conference on  (Volume:3 )

Date of Conference:

14-19 Sept. 2003