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Programmable analog signal conditioning circuits can be programmed in the field to permit their use in several applications with a variety of sensors with different output signal characteristics. The digital programming of the gain and dc level shift of a conditioning circuit can affect the measurement resolution and cause a reduction in the range of the measuring system in which it is employed. For a specified maximum acceptable loss in the measurement resolution, a procedure for defining and employing the programming values that guarantees the full measurement range is proposed. The proposed methodology takes into account practical implementation considerations and can be employed for designing either discrete or integrated circuits.