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Validation and evaluation of model-based cross-talk compensation method in simultaneous 99mTc stress and 201Tl rest myocardial perfusion SPECT

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5 Author(s)
X. Song ; Johns Hopkins Univ., Baltimore, MD, USA ; E. C. Frey ; W. T. Wang ; Y. Du
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Simultaneous acquisition of 99mTc stress and 201Tl rest myocardial perfusion SPECT has several potential advantages, but the image quality is degraded by cross-talk between the Tc and Tl data. We have previously developed down-scatter and Pb X-ray models for cross-talk compensation. In this work, we validated these models by comparing the crosstalk from 99Tc to the Tl window calculated using our models with the cross-talk simulated using a combination of the SimSET-MCNP Monte Carlo simulation codes. We have also evaluated the model-based cross-talk compensation method using both simulated data from MCAT phantoms and experimental data from a physical phantom with a myocardial defect. In the studies the Tl distributions were reconstructed from cross-talk contaminated data without cross-talk compensation, with compensation using the model-calculated cross-talk or using the true cross-talk, and were compared with that from uncontaminated Tl data. Results show that the models gave good estimates of both the down-scatter photons and Pb X-rays in the simultaneous dual isotopes myocardial perfusion SPECT. Also, the results show that model-based cross-talk compensation method provided image quality significantly improved as compared to no compensation and very close to that from the separate acquisition.

Published in:

Nuclear Science Symposium Conference Record, 2002 IEEE  (Volume:3 )

Date of Conference:

10-16 Nov. 2002