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This paper presents a method to identify the structure of generalized adaptive neuro-fuzzy inference systems (GANFISs). The structure of GANFIS consists of a number of generalized radial basis function (GRBF) units. The radial basis functions are irregularly distributed in the form of hyper-patches in the input-output space. The minimum number of GRBF units is selected based on a heuristic using the fuzzy curve. For structure identification, a new criterion called structure identification criterion (SIC) is proposed. SIC deals with a trade off between performance and computational complexity of the GANFIS model. The computational complexity of gradient descent learning is formulated based on simulation study. Three methods of initialization of GANFIS, viz., fuzzy curve, fuzzy C-means in x×y space and modified mountain clustering have been compared in terms of cluster validity measure, Akaike's information criterion (AIC) and the proposed SIC.