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Mathematical modeling in genetic networks: relationships between the genetic expression and both chromosomic breakage and positive circuits

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5 Author(s)
Aracena, J. ; Univ. de Chile, Santiago, Chile ; Lamine, S.B. ; Mermet, M.A. ; Cohen, O.
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The human genome with its 23 pairs of chromosomes, is the result of evolution. This evolution has been ruled by the mutation process and also by the physiological and pathological reorganization of the genomic material inside or between the chromosomes, which are conditioning the genomic variability. This reorganization is starting at singular points on the short or long chromosomic arms, called crossing-over, or translocations, insertions, break points. In this paper, we will show that these points, also called weak points or hot spots of the genome are correlated, independently of their origin. In addition, we will give some properties of the genetic interaction matrices in terms of attractors of the genetic expression dynamics.

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Systems, Man, and Cybernetics, Part B: Cybernetics, IEEE Transactions on  (Volume:33 ,  Issue: 5 )