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Mining residue contacts in proteins using local structure predictions

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3 Author(s)
M. J. Zaki ; Comput. Sci. Dept., Rensselaer Polytech. Inst., Troy, NY, USA ; Shan Jin ; C. Bystroff

In this paper we develop data mining techniques to predict 3D contact potentials among protein residues (or amino acids) based on the hierarchical nucleation-propagation model of protein folding. We apply a hybrid approach, using a hidden Markov model to extract folding initiation sites, and then apply association mining to discover contact potentials. The new hybrid approach achieves accuracy results better than those reported previously.

Published in:

IEEE Transactions on Systems, Man, and Cybernetics, Part B (Cybernetics)  (Volume:33 ,  Issue: 5 )