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The paper deals with the performance evaluation of a pilot-aided channel parameter estimation method suitable for applications in direct-sequence code-division multiple-access (DS-CDMA) communication systems. Differently from previous approaches, a suitable selective interference cancellation algorithm is used in order to reduce multipath interference on the channel parameter estimation and the detection of the information-bearing signals due to pilot signal replicas. Simulation results demonstrate the good channel parameter estimation capability of the proposed method in the case of uplink communications and different types of receiving schemes. In order to highlight the good behavior of the proposed approach, performance comparisons are shown with the ideal case of perfect knowledge of the channel parameter values, as well as with the classical implementation of the considered channel parameter estimation algorithm.