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Sharp and repetitive stripes exist in many bands of Chinese Moderate Imaging Spectroradiometer (CMODIS) images because of gain and offset variations between neighboring forward and reverse scans of 22 detectors, which can distractingly and obstructively affect the interpretation and application of CMODIS data. In this letter, we suggest a method for destriping based on a finite-impulse response (FIR) filter in frequency domain and present the results obtained with the method on the experimental CMODIS images of heterogeneous targets. We also compare the method with some traditional destriping methods (e.g. lowpass filtering, moment matching) and display the result of comparison using one of the images. The destriping effectiveness is evaluated by means of appropriate indexes of quality in this letter.